Pathway Details

Recommended name

Terpenoid backbone biosynthesis

Alternative names

Reactions

beta-Carotene <-> Echinenone

beta-Carotene <-> Zeaxanthin

Isopentenyl diphosphate + trans,trans-Farnesyl diphosphate <-> Diphosphate + Geranylgeranyl diphosphate

ATP + Mevalonate <-> ADP + Mevalonate 5-phosphate

Vitamin K epoxide + Gla protein <-> Gla protein precursor + Reduced vitamin K

Reduced acceptor + 7-Dehydrodesmosterol <-> Acceptor + 5alpha-Cholesta-7,24-dien-3beta-ol

2 S-Adenosyl-L-methionine + Desmosterol <-> 2 S-Adenosyl-L-homocysteine + Phytosterol

ATP + 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol <-> ADP + 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ATP + (R)-5-Diphosphomevalonate <-> ADP + Phosphate + CO2 + Isopentenyl diphosphate

5,6beta-Epoxy-5alpha-cholestane <-> 5alpha-Cholestan-5,6beta-diol

Vitamin K <-> Vitamin K epoxide

(S)-2,3-Epoxysqualene <-> Cycloartenol

2 H+ + 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate <-> H2O + Isopentenyl diphosphate

trans,trans-Farnesyl diphosphate + Protein cysteine <-> Diphosphate + S-Farnesyl protein

Dimethylallyl diphosphate + Isopentenyl diphosphate <-> Diphosphate + Geranyl diphosphate

H+ + NADPH + 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate <-> H2O + NADP+ + Isopentenyl diphosphate

H+ + NADPH + Lanosterol <-> NADP+ + 24,25-Dihydrolanosterol

4 Isopentenyl diphosphate + trans,trans-Farnesyl diphosphate <-> 4 Diphosphate + All-trans-Heptaprenyl diphosphate

O2 + 5alpha-Cholest-7-en-3beta-ol <-> H2O2 + Cholesta-5,7-dien-3beta-ol

Isopentenyl diphosphate <-> Dimethylallyl diphosphate

2 Geranylgeranyl diphosphate <-> H+ + Diphosphate + Prephytoene diphosphate

2 H+ + 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate <-> H2O + 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate

H+ + NADPH + Presqualene diphosphate <-> NADP+ + Diphosphate + Squalene

2 NADP+ + Coenzyme A + (R)-Mevalonate <-> 2 H+ + 2 NADPH + 3-Hydroxy-3-methylglutaryl-CoA

4alpha-Methylcholesta-8-en-3beta-ol <-> Methostenol

Isopentenyl diphosphate + all-trans-Hexaprenyl diphosphate <-> Diphosphate + All-trans-Heptaprenyl diphosphate

Lycopene <-> gamma-Carotene

2 NAD+ + Coenzyme A + Mevalonate <-> 2 NADH + 2 H+ + 3-Hydroxy-3-methylglutaryl-CoA

Ubiquinone + Menaquinone <-> Isopentenyl diphosphate + Geranylgeranyl diphosphate + RING

Diphosphate + Vitamin K <-> H+ + Phytyl diphosphate + RING

Acceptor + beta-Carotene <-> H+ + Reduced acceptor + gamma-Carotene

Isopentenyl diphosphate + Geranyl diphosphate <-> Diphosphate + trans,trans-Farnesyl diphosphate

ATP + (R)-5-Phosphomevalonate <-> ADP + (R)-5-Diphosphomevalonate

H+ + NADPH + 5-Cholestene <-> H2O + NADP+ + 5,6beta-Epoxy-5alpha-cholestane

ATP + (R)-Mevalonate <-> ADP + (R)-5-Phosphomevalonate

D-Glyceraldehyde 3-phosphate + Pyruvate <-> CO2 + 1-Deoxy-D-xylulose 5-phosphate

Ergosterol <-> Vitamin D2

5,6beta-Epoxy-5beta-cholestane <-> 5alpha-Cholestan-5,6beta-diol

H+ + NADPH + O2 + Lanosterol <-> NADP+ + Formate + 14-Demethyllanosterol

Diphosphate + alpha-Tocopherol <-> H+ + Phytyl diphosphate + RING

6 H+ + 6 NADPH + 6 O2 + 14-Demethyllanosterol <-> 8 H2O + 6 NADP+ + 2 CO2 + Zymosterol

Acceptor + Ergosterol <-> 2 H+ + Reduced acceptor + Ergosta-5,7,22,24(28)-tetraen-3beta-ol

Cholesta-5,7-dien-3beta-ol <-> Vitamin D3

O2 + Reduced acceptor + Neurosporene <-> 2 H2O + Acceptor + Lycopene

poly-cis-Polyprenyl diphosphate + Isopentenyl diphosphate <-> Diphosphate + Rubber particle

NAD+ + Cholesterol <-> NADH + H+ + Cholesta-5,7-dien-3beta-ol

Phytoene <-> Hydrogen + Phytofluene

Acceptor + Lycopene <-> Reduced acceptor + Hydrogen + alpha-Carotene

2 Acetyl-CoA <-> Coenzyme A + Acetoacetyl-CoA

NADP+ + 2-C-Methyl-D-erythritol 4-phosphate <-> H+ + NADPH + 1-Deoxy-D-xylulose 5-phosphate

(S)-2,3-Epoxysqualene <-> Lanosterol

Zeaxanthin <-> Violaxanthin

5 Isopentenyl diphosphate + trans,trans-Farnesyl diphosphate <-> 5 Diphosphate + all-trans-Octaprenyl diphosphate

S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <-> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester

H2O + Cholesterol-5alpha,6beta-epoxide <-> 3beta,5alpha,6beta-Cholestanetriol

CTP + 2-C-Methyl-D-erythritol 4-phosphate <-> Diphosphate + 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2 NAD+ + Coenzyme A + (R)-Mevalonate <-> 2 NADH + H+ + 3-Hydroxy-3-methylglutaryl-CoA

H+ + NADPH + O2 + 5-Cholestene <-> H2O + NADP+ + 5,6beta-Epoxy-5beta-cholestane

2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol <-> CMP + 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate

Acceptor + Phytofluene <-> Reduced acceptor + Hydrogen + zeta-Carotene

NADP+ + 2-trans,6-trans-Farnesol <-> H+ + NADPH + 2-trans,6-trans-Farnesal

H+ + NADPH + O2 + Calcidiol <-> H2O + NADP+ + Calcitriol

Phytofluene <-> zeta-Carotene

H2O + Oxidized ferredoxin + Calcidiol <-> O2 + Reduced ferredoxin + Vitamin D3

Coenzyme A + 3-Hydroxy-3-methylglutaryl-CoA <-> H2O + Acetyl-CoA + Acetoacetyl-CoA

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + Cholesterol-5beta,6beta-epoxide

H+ + NADPH + 24,25-Dihydrolanosterol <-> NADP+ + 4alpha-Methylcholesta-8-en-3beta-ol

NAD+ + Farnesol <-> NADH + H+ + Farnesal

H2O + NADP+ + Dimethylallyl diphosphate <-> H+ + NADPH + 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate

H2O + Cholesterol-5beta,6beta-epoxide <-> 3beta,5alpha,6beta-Cholestanetriol

All-trans-Pentaprenyl diphosphate + Isopentenyl diphosphate <-> Diphosphate + all-trans-Hexaprenyl diphosphate

Acceptor + beta-Zeacarotene <-> Reduced acceptor + Hydrogen + gamma-Carotene

NADP+ + Cholesterol <-> H+ + NADPH + Cholesta-5,7-dien-3beta-ol

NADP+ + Cholesterol <-> H+ + NADPH + Desmosterol

2 trans,trans-Farnesyl diphosphate <-> H+ + Diphosphate + Presqualene diphosphate

S-Adenosyl-L-methionine + Desmosterol <-> S-Adenosyl-L-homocysteine + Ergosta-5,7,22,24(28)-tetraen-3beta-ol

Acceptor + Desmosterol <-> Reduced acceptor + 7-Dehydrodesmosterol

H+ + NADPH + Prephytoene diphosphate <-> NADP+ + Diphosphate + cis-Phytoene

H+ + Acceptor + Neurosporene <-> Reduced acceptor + beta-Zeacarotene

Violaxanthin <-> Abscisate

Cycloartenol <-> Zymosterol

14-Demethyllanosterol <-> 4alpha-Methylcholesta-8-en-3beta-ol

Phytyl diphosphate + Chlorophyllide <-> Diphosphate + Chlorophylls

zeta-Carotene <-> Hydrogen + Neurosporene

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + Cholesterol-5alpha,6beta-epoxide

Dimethylallyl diphosphate <-> Diphosphate + Isoprene

NADH + H+ + Vitamin K <-> NAD+ + Reduced vitamin K

H+ + 3 NADPH + Geranylgeranyl diphosphate <-> 3 NADP+ + Phytyl diphosphate

Classification

Metabolism of Terpenoids and Polyketides