Reaction Details
Reaction ID
523
Stochiometric Equation
Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA
Substrates
NAD+
Pyruvate
Coenzyme A
Products
CO2
Acetyl-CoA
H+
NADH
Enzymes known to
catalyse this reaction
(curated information)
EC Number
in Organism
UniProtKB Link
PubMedID
1.2.4.1
Escherichia coli
UniProtKB
12751797
1.2.4.1
Escherichia coli
UniProtKB
16027371
1.2.4.1
Homo sapiens
UniProtKB
8548923
1.2.4.1
Mycobacterium bovis
UniProtKB
16027371
1.2.4.1
Mycobacterium smegmatis
UniProtKB
16027371
1.2.4.1
Mycobacterium tuberculosis
UniProtKB
16027371
1.2.4.1
Pisum sativum
UniProtKB
16667685
1.2.4.1
Scheffersomyces stipitis
UniProtKB
8669897
1.2.4.1
Solanum tuberosum
UniProtKB
16667685
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Bos taurus
UniProtKB
4357736
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Corynebacterium glutamicum
UniProtKB
20675489
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Enterococcus faecalis
UniProtKB
1730230
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Escherichia coli
UniProtKB
11583990
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Escherichia coli
UniProtKB
8969175
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Homo sapiens
UniProtKB
11485553
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Homo sapiens
UniProtKB
2087902
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Lactococcus lactis subsp. lactis
UniProtKB
1624471
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Mycobacterium tuberculosis
UniProtKB
16045627
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Solanum tuberosum
UniProtKB
9729464
Complex:
1.2.4.1
/
2.3.1.12
/
1.8.1.4
Sus scrofa
UniProtKB
5812959
Complex:
1.2.4.2
/
2.3.1.61
/
1.8.1.4
Azotobacter vinelandii
UniProtKB
10848975
Complex:
1.2.4.4
/
2.3.1.168
Bos taurus
UniProtKB
283398
Complex:
1.2.4.4
/
2.3.1.168
Oryctolagus cuniculus
UniProtKB
7142221
Complex:
1.2.4.4
/
2.3.1.168
/
1.8.1.4
Homo sapiens
UniProtKB
3593587
Complex:
1.2.4.4
/
2.3.1.168
/
1.8.1.4
Rattus norvegicus
UniProtKB
3571202
Pathways
Biosynthesis of secondary metabolites
Carbon metabolism
Glycolysis/Gluconeogenesis
Metabolic pathways
Microbial metabolism in diverse environments
Pyruvate metabolism
External Links
KEGG-Pathway-ID
map01110
map01200
map00010
map01100
map01120
map00620
KEGG-Reaction-ID
R00209
MetaNetX-Reaction-ID
MNXR102425
Rhea-Reaction-ID
28043
28042
28045
28044
Reactome-Reaction-ID
R-SCE-71397
R-GGA-373177
R-CFA-71397
R-RNO-71397
R-DME-71397
R-HSA-71397
R-SSC-71397
R-DRE-71397
R-TGU-71397
R-MMU-71397
R-SPO-71397
R-OSA-71397
R-XTR-71397
R-BTA-71397
R-CEL-71397
R-ATH-71397
R-DDI-71397
R-GGA-71397
MetaCyc-Reaction-ID
PYRUVDEH-RXN
View all entries for reaction Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA
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