Reaction Details

Reaction ID

7840

Stochiometric Equation

H+ + NADPH + 5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + NADP+ + 5,6,7,8-Tetrahydrofolate

Substrates

dUMP

H+

5,10-Methylenetetrahydrofolate

NADPH

Products

dTMP

5,6,7,8-Tetrahydrofolate

NADP+

Enzymes known to
catalyse this reaction
(curated information)

EC Number	in Organism	UniProtKB Link	PubMedID
2.1.1.148	Chlamydia trachomatis	UniProtKB	15591067
2.1.1.148	Thermotoga maritima	UniProtKB	15301527
Complex: 1.5.1.3 / 2.1.1.45	Leishmania major	UniProtKB	12556445
Complex: 1.5.1.3 / 2.1.1.45	Toxoplasma gondii	UniProtKB	12556445

Pathways

Metabolic pathways
One carbon pool by folate
Pyrimidine metabolism

External Links

KEGG-Pathway-ID

map01100
map00670
map00240

KEGG-Reaction-ID

R06613

MetaNetX-Reaction-ID

MNXR104890

Rhea-Reaction-ID

29045 29046 29043 29044