Pathway Details

Recommended name

Folate biosynthesis

Alternative names

Reactions

ATP + Formate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolate

5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + Dihydrofolate

NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate

3 H2O + GTP <-> Diphosphate + Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine

H2O + GTP <-> Formamidopyrimidine nucleoside triphosphate

NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Dihydrofolate

NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Folate

2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate

ATP + L-Glutamate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](2)

ATP + L-Glutamate + 10-Formyltetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolyl L-glutamate

L-Glutamine + Chorismate <-> L-Glutamate + 4-Amino-4-deoxychorismate

NADH + H+ + 6,7-Dihydrobiopterin <-> NAD+ + Tetrahydrobiopterin

H+ + NADPH + 6,7-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin

2 NADP+ + Tetrahydrobiopterin <-> 2 H+ + 2 NADPH + Biopterin

NADP+ + Tetrahydrobiopterin <-> H+ + NADPH + 6-Lactoyl-5,6,7,8-tetrahydropterin

NAD+ + Dihydrofolate <-> NADH + H+ + Folate

NADP+ + Dihydrofolate <-> H+ + NADPH + Folate

ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate

NADP+ + 7,8-Dihydrobiopterin <-> H+ + NADPH + Sepiapterin

H2O + Acceptor + Formylmethanofuran <-> CO2 + Reduced acceptor + Methanofuran

Coenzyme F420 + Hydrogen <-> Reduced coenzyme F420

4-Aminobenzoate + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <-> H2O + Dihydropteroate

2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-Aminobenzoate <-> Diphosphate + Dihydropteroate

NADP+ + 5,6,7,8-Tetrahydromethanopterin <-> H+ + NADPH + 7,8-Dihydromethanopterin

Formylmethanofuran + 5,6,7,8-Tetrahydromethanopterin <-> Methanofuran + 5-Formyl-5,6,7,8-tetrahydromethanopterin

H2O + 5,10-Methenyltetrahydromethanopterin <-> 5-Formyl-5,6,7,8-tetrahydromethanopterin

ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <-> AMP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate

7,8-Dihydroneopterin <-> Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine

ATP + L-Glutamate + Tetrahydrofolyl-[Glu](n) <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](n)

Tetrahydrofolyl-[Glu](n) <-> 5,6,7,8-Tetrahydrofolate + Poly-L-glutamate

NADP+ + 6-Lactoyl-5,6,7,8-tetrahydropterin <-> H+ + NADPH + 6-Pyruvoyltetrahydropterin

H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin

2-Mercaptoethanesulfonate + 5-Methyl-5,6,7,8-tetrahydromethanopterin <-> 5,6,7,8-Tetrahydromethanopterin + 2-(Methylthio)ethanesulfonate

Coenzyme F420 + 5,10-Methylenetetrahydromethanopterin <-> Reduced coenzyme F420 + 5,10-Methenyltetrahydromethanopterin

Reduced coenzyme F420 + 5,10-Methylenetetrahydromethanopterin <-> Coenzyme F420 + 5-Methyl-5,6,7,8-tetrahydromethanopterin

Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + Dihydromethanophenazine <-> N-(7-Mercaptoheptanoyl)threonine O3-phosphate + 2-Mercaptoethanesulfonate + Methanophenazine

N-(7-Mercaptoheptanoyl)threonine O3-phosphate + 2-(Methylthio)ethanesulfonate <-> Methane + Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide

3 H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 3 Phosphate + 7,8-Dihydroneopterin

Phosphate + 7,8-Dihydroneopterin <-> H2O + Dihydroneopterin phosphate

Acceptor + 7,8-Dihydroneopterin <-> Reduced acceptor + Neopterin

2 H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2 Phosphate + Molybdopterin

H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Diphosphate + Dihydroneopterin phosphate

H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine

(6R)-6-(L-erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin <-> H2O + (6R)-6-(L-erythro-1,2-Dihydroxypropyl)-7,8-dihydro-6H-pterin

H2O + Formamidopyrimidine nucleoside triphosphate <-> Formate + 2,5-Diaminopyrimidine nucleoside triphosphate

Formate + Formamidopyrimidine nucleoside triphosphate <-> 2,5-Diaminopyrimidine nucleoside triphosphate

2,5-Diaminopyrimidine nucleoside triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine

2 S-Adenosyl-L-methionine + 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine <-> H2O + 2 S-Adenosyl-L-homocysteine + 6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin

n-1 ATP + n-1 L-Glutamate + 10-Formyltetrahydrofolyl L-glutamate <-> n-1 ADP + n-1 Phosphate + 10-Formyltetrahydrofolylpolyglutamate

NH3 + Chorismate <-> H2O + 4-Amino-4-deoxychorismate

4-Amino-4-deoxychorismate <-> Pyruvate + 4-Aminobenzoate

L-Tyrosine + O2 + Tetrahydrobiopterin <-> L-Dopa + 4a-Hydroxytetrahydrobiopterin

H+ + NADPH + 7,8-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin

L-Phenylalanine + O2 + Tetrahydrobiopterin <-> L-Tyrosine + 4a-Hydroxytetrahydrobiopterin

L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin

7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin

NADH + H+ + 2-Amino-4-hydroxy-6,7-dimethyldihydropteridine <-> NAD+ + 2-Amino-4-hydroxy-6,7-dimethyltetrahydropteridine

H+ + NADPH + 2-Amino-4-hydroxy-6,7-dimethyldihydropteridine <-> NADP+ + 2-Amino-4-hydroxy-6,7-dimethyltetrahydropteridine

H2O + Dihydroneopterin triphosphate <-> Diphosphate + Dihydroneopterin phosphate

2 NADPH + 7-Cyano-7-deazaguanine <-> 2 NADP+ + 7-Aminomethyl-7-deazaguanine

NADH + H+ + Quinonoid 6,7-dimethyl dihydropterin <-> NAD+ + 6,7-Dimethyl tetrahydropterin

H+ + NADPH + Quinonoid 6,7-dimethyl dihydropterin <-> NADP+ + 6,7-Dimethyl tetrahydropterin

H+ + NADPH + Quinonoid 7,8-dihydropterin <-> NADP+ + Tetrahydropterin

NADH + H+ + Quinonoid 7,8-dihydropterin <-> NAD+ + Tetrahydropterin

7,8-Dihydroneopterin <-> 7,8-Dihydromonapterin

7,8-Dihydroneopterin 3'-triphosphate <-> 7,8-Dihydromonapterin 3'-triphosphate

Classification

Metabolism of Cofactors and Vitamins